2anw: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2anw.png|left|200px]]
 {{STRUCTURE_2anw|  PDB=2anw  |  SCENE=  }}
+===Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors===
+{{ABSTRACT_PUBMED_16199530}}
-===Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors===
+==Disease==
+[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[http://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
-{{ABSTRACT_PUBMED_16199530}}
+==Function==
+[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:016199530</ref><references group="xtra"/>
+<ref group="xtra">PMID:016199530</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Plasma kallikrein]]