2lvm: Difference between revisions
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{{STRUCTURE_2lvm| PDB=2lvm | SCENE= }} | {{STRUCTURE_2lvm| PDB=2lvm | SCENE= }} | ||
===Solution structure of human 53BP1 tandem Tudor domains in complex with a histone H4K20me2 peptide=== | |||
{{ABSTRACT_PUBMED_23377543}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref><ref>PMID:17190600</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2lvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVM OCA]. | [[2lvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVM OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Botuyan, M.]] | [[Category: Botuyan, M.]] | ||