1fvo: Difference between revisions

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-{{Seed}}
-[[Image:1fvo.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1fvo", creates the "Structure Box" on the page.
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-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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 {{STRUCTURE_1fvo|  PDB=1fvo  |  SCENE=  }}
 ===CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMYLASE COMPLEXED WITH CARBAMOYL PHOSPHATE===
+{{ABSTRACT_PUBMED_11237854}}
+==Disease==
-<!--
+[[http://www.uniprot.org/uniprot/OTC_HUMAN OTC_HUMAN]] Defects in OTC are the cause of ornithine carbamoyltransferase deficiency (OTCD) [MIM:[http://omim.org/entry/311250 311250]]. OTCD is an X-linked disorder of the urea cycle which causes a form of hyperammonemia. Mutations with no residual enzyme activity are always expressed in hemizygote males by a very severe neonatal hyperammonemic coma that generally proves to be fatal. Heterozygous females are either asymptomatic or express orotic aciduria spontaneously or after protein intake. The disorder is treatable with supplemental dietary arginine and low protein diet. The arbitrary classification of patients into the 'neonatal' group (clinical hyperammonemia in the first few days of life) and 'late' onset (clinical presentation after the neonatal period) has been used to differentiate severe from mild forms.<ref>PMID:8081373</ref><ref>PMID:3170748</ref><ref>PMID:2474822</ref><ref>PMID:2347583</ref><ref>PMID:1671317</ref><ref>PMID:1721894</ref><ref>PMID:1480464</ref><ref>PMID:8099056</ref><ref>PMID:8019569</ref><ref>PMID:8081398</ref><ref>PMID:7951259</ref><ref>PMID:8530002</ref><ref>PMID:7474905</ref><ref>PMID:8807340</ref>[:]<ref>PMID:8956038</ref><ref>PMID:8956045</ref><ref>PMID:8830175</ref><ref>PMID:9286441</ref><ref>PMID:9065786</ref><ref>PMID:9143919</ref><ref>PMID:9266388</ref><ref>PMID:9452024</ref><ref>PMID:9452049</ref><ref>PMID:9452065</ref>[:]<ref>PMID:10502831</ref><ref>PMID:10070627</ref><ref>PMID:10737985</ref><ref>PMID:11793483</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_11237854}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11237854 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11237854}}
 ==About this Structure==
-FVO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVO OCA].
+[[1fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVO OCA].
 ==Reference==
-<ref group="xtra">PMID:11237854</ref><references group="xtra"/>
+<ref group="xtra">PMID:011237854</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Ornithine carbamoyltransferase]]
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 [[Category: Yu, X.]]
 [[Category: Alpha/beta topology]]
+[[Category: Transferase]]
 [[Category: Two domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:52:15 2009''