1p8d: Difference between revisions

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m Protected "1p8d" [edit=sysop:move=sysop]
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[[Image:1p8d.png|left|200px]]
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{{STRUCTURE_1p8d|  PDB=1p8d  |  SCENE=  }}  
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===X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol===
===X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol===
{{ABSTRACT_PUBMED_12736258}}


 
==Function==
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[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).  
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{{ABSTRACT_PUBMED_12736258}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:012736258</ref><references group="xtra"/>
<ref group="xtra">PMID:012736258</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bledsoe, R K.]]
[[Category: Bledsoe, R K.]]

Revision as of 23:47, 24 March 2013

Template:STRUCTURE 1p8d

X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterolX-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol

Template:ABSTRACT PUBMED 12736258

FunctionFunction

[NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

About this StructureAbout this Structure

1p8d is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM. X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. J Biol Chem. 2003 Jul 18;278(29):27138-43. Epub 2003 May 7. PMID:12736258 doi:http://dx.doi.org/10.1074/jbc.M302260200

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OCA
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