1zn7: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1zn7.png|left|200px]]
 {{STRUCTURE_1zn7|  PDB=1zn7  |  SCENE=  }}
+===Human Adenine Phosphoribosyltransferase Complexed with PRPP, ADE and R5P===
+{{ABSTRACT_PUBMED_18399692}}
-===Human Adenine Phosphoribosyltransferase Complexed with PRPP, ADE and R5P===
+==Disease==
+[[http://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:[http://omim.org/entry/614723 614723]]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.<ref>PMID:1746557</ref><ref>PMID:7915931</ref><ref>PMID:3680503</ref><ref>PMID:3343350</ref><ref>PMID:1353080</ref><ref>PMID:11243733</ref><ref>PMID:15571218</ref><ref>PMID:21635362</ref>
-{{ABSTRACT_PUBMED_18399692}}
+==Function==
+[[http://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN]] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:018399692</ref><references group="xtra"/>
+<ref group="xtra">PMID:018399692</ref><references group="xtra"/><references/>
 [[Category: Adenine phosphoribosyltransferase]]
 [[Category: Homo sapiens]]