5tsw: Difference between revisions

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-{{Seed}}
-[[Image:5tsw.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_5tsw", creates the "Structure Box" on the page.
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-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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 {{STRUCTURE_5tsw|  PDB=5tsw  |  SCENE=  }}
 ===HIGH RESOLUTION CRYSTAL STRUCTURE OF A HUMAN TNF-ALPHA MUTANT===
+{{ABSTRACT_PUBMED_9442056}}
+==Disease==
+[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_9442056}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref>  The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 9442056 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_9442056}}
 ==About this Structure==
-TSW is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4tsw 4tsw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSW OCA].
+[[5tsw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4tsw 4tsw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSW OCA].
 ==Reference==
-<ref group="xtra">PMID:9442056</ref><references group="xtra"/>
+<ref group="xtra">PMID:009442056</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cha, S S.]]
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 [[Category: Lymphokine]]
 [[Category: Mutant]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:09:28 2009''