1nyx: Difference between revisions
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{{STRUCTURE_1nyx| PDB=1nyx | SCENE= }} | {{STRUCTURE_1nyx| PDB=1nyx | SCENE= }} | ||
===Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist=== | ===Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist=== | ||
{{ABSTRACT_PUBMED_12672231}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PPAT_HUMAN PPAT_HUMAN]] Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.<ref>PMID:15219672</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012672231</ref><references group="xtra"/> | <ref group="xtra">PMID:012672231</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Deussen, H J.]] | [[Category: Deussen, H J.]] | ||
Revision as of 22:28, 24 March 2013
Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonistLigand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist
Template:ABSTRACT PUBMED 12672231
FunctionFunction
[PPAT_HUMAN] Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.[1]
About this StructureAbout this Structure
1nyx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Ebdrup S, Pettersson I, Rasmussen HB, Deussen HJ, Frost Jensen A, Mortensen SB, Fleckner J, Pridal L, Nygaard L, Sauerberg P. Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar. J Med Chem. 2003 Apr 10;46(8):1306-17. PMID:12672231 doi:10.1021/jm021027r
- ↑ Fleisig H, El-Din El-Husseini A, Vincent SR. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Neuroscience. 2004;127(1):91-100. PMID:15219672 doi:10.1016/j.neuroscience.2004.04.060