1dst: Difference between revisions
m Protected "1dst" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1dst| PDB=1dst | SCENE= }} | {{STRUCTURE_1dst| PDB=1dst | SCENE= }} | ||
===MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY=== | |||
{{ABSTRACT_PUBMED_7592653}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[http://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:007592653</ref><references group="xtra"/> | <ref group="xtra">PMID:007592653</ref><references group="xtra"/><references/> | ||
[[Category: Complement factor D]] | [[Category: Complement factor D]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||