1nql: Difference between revisions
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{{STRUCTURE_1nql| PDB=1nql | SCENE= }} | {{STRUCTURE_1nql| PDB=1nql | SCENE= }} | ||
===Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.=== | |||
{{ABSTRACT_PUBMED_12620237}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN]] Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:[http://omim.org/entry/611718 611718]]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.<ref>PMID:17671655</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN]] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.<ref>PMID:17671655</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012620237</ref><references group="xtra"/> | <ref group="xtra">PMID:012620237</ref><references group="xtra"/><references/> | ||
[[Category: Epidermal Growth Factor Receptor]] | [[Category: Epidermal Growth Factor Receptor]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||