2k6t: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2k6t.png|left|200px]]
 {{STRUCTURE_2k6t|  PDB=2k6t  |  SCENE=  }}
+===Solution structure of the relaxin-like factor===
+{{ABSTRACT_PUBMED_19086273}}
-===Solution structure of the relaxin-like factor===
+==Disease==
+[[http://www.uniprot.org/uniprot/INSL3_HUMAN INSL3_HUMAN]] Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:[http://omim.org/entry/219050 219050]]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.<ref>PMID:11095425</ref><ref>PMID:11746019</ref><ref>PMID:12601553</ref>
-{{ABSTRACT_PUBMED_19086273}}
+==Function==
+[[http://www.uniprot.org/uniprot/INSL3_HUMAN INSL3_HUMAN]] Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:019086273</ref><references group="xtra"/>
+<ref group="xtra">PMID:019086273</ref><references group="xtra"/><references/>
 [[Category: Bullesbach, E E.]]
 [[Category: Hansen, D F.]]