1q11: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1q11.png|left|200px]]
 {{STRUCTURE_1q11|  PDB=1q11  |  SCENE=  }}
+===Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol===
+{{ABSTRACT_PUBMED_14671330}}
-===Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol===
+==Disease==
+[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[http://omim.org/entry/608323 608323]]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>
-{{ABSTRACT_PUBMED_14671330}}
+==Function==
+[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:014671330</ref><references group="xtra"/>
+<ref group="xtra">PMID:014671330</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Tyrosine--tRNA ligase]]