3d6g: Difference between revisions

Revision as of 15:22, 24 March 2013

Fc fragment of IgG1 (Herceptin) with protein-A mimetic peptide dendrimer ligand.Fc fragment of IgG1 (Herceptin) with protein-A mimetic peptide dendrimer ligand.

DiseaseDisease

[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

About this StructureAbout this Structure

3d6g is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

Revision as of 15:22, 24 March 2013 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits No edit summary ← Older edit	Revision as of 15:22, 24 March 2013 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits m Protected "3d6g" [edit=sysop:move=sysop] Newer edit →
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