2c6b: Difference between revisions

Revision as of 17:45, 21 February 2008

SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2

OverviewOverview

HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.

About this StructureAbout this Structure

2C6B is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008

Page seeded by OCA on Thu Feb 21 16:45:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2c6b.gif|left|200px]]<br />
+[[Image:2c6b.gif|left|200px]]<br /><applet load="2c6b" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2c6b" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2c6b" />
 '''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2'''<br />
 ==Overview==
-HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the, tumor suppressor p53. Here, we report the determination of the solution, structure of the C4 zinc finger domain of HDM2 using multidimensional NMR., The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix, followed by four beta-strands, which shares significant structural, similarity to the zinc ribbon protein family. Family based sequence, analysis identified two putative binding sites, one of which resembles an, RNA binding motif.
+HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.
 ==About this Structure==
-C6B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C6B OCA].
+C6B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6B OCA].
 ==Reference==
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 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Allen, M.D.]]
+[[Category: Allen, M D.]]
 [[Category: Andreeva, A.]]
 [[Category: Bycroft, M.]]
-[[Category: Fersht, A.R.]]
+[[Category: Fersht, A R.]]
-[[Category: Yu, G.W.]]
+[[Category: Yu, G W.]]
 [[Category: ZN]]
 [[Category: alternative splicing]]
@@ Line 31: / Line 30: @@
 [[Category: zinc finger]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:11:29 2007''
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