3fit: Difference between revisions

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OCA

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-[[Image:3fit.png|left|200px]]
 {{STRUCTURE_3fit|  PDB=3fit  |  SCENE=  }}
+===FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) IN COMPLEX WITH ADENOSINE/SULFATE AMP ANALOG===
+{{ABSTRACT_PUBMED_9261067}}
-===FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) IN COMPLEX WITH ADENOSINE/SULFATE AMP ANALOG===
+==Disease==
+[[http://www.uniprot.org/uniprot/FHIT_HUMAN FHIT_HUMAN]] Note=A chromosomal aberration involving FHIT has been found in a lymphoblastoid cell line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation t(3;8)(p14.2;q24.1) with RNF139. Although the 3p14.2 breakpoint has been shown to interrupt FHIT in its 5-prime non-coding region, it is unlikely that FHIT is causally related to renal or other malignancies.<ref>PMID:15007172</ref>  Note=Associated with digestive tract cancers. Numerous tumor types are found to have aberrant forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the fragile site locus FRA3B.<ref>PMID:15007172</ref>
-{{ABSTRACT_PUBMED_9261067}}
+==Function==
+[[http://www.uniprot.org/uniprot/FHIT_HUMAN FHIT_HUMAN]] Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.<ref>PMID:8794732</ref>
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:009261067</ref><references group="xtra"/>
+<ref group="xtra">PMID:009261067</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Amico, K L.D.]]