1k78: Difference between revisions
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{{STRUCTURE_1k78| PDB=1k78 | SCENE= }} | {{STRUCTURE_1k78| PDB=1k78 | SCENE= }} | ||
===Pax5(1-149)+Ets-1(331-440)+DNA=== | |||
{{ABSTRACT_PUBMED_11779502}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PAX5_HUMAN PAX5_HUMAN]] Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ETS1_MOUSE ETS1_MOUSE]] Transcription factor. [[http://www.uniprot.org/uniprot/PAX5_HUMAN PAX5_HUMAN]] May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011779502</ref><references group="xtra"/> | <ref group="xtra">PMID:011779502</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||