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[[Image:3svg.jpg|left|200px]]
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{{STRUCTURE_3svg|  PDB=3svg  |  SCENE=  }}  
{{STRUCTURE_3svg|  PDB=3svg  |  SCENE=  }}  
===Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand===
{{ABSTRACT_PUBMED_021851057}}


===Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand===
==Disease==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref>


==Function==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


==About this Structure==
==About this Structure==
[[3svg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVG OCA].  
[[3svg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVG OCA].  
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]

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