2nsm: Difference between revisions
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{{STRUCTURE_2nsm| PDB=2nsm | SCENE= }} | {{STRUCTURE_2nsm| PDB=2nsm | SCENE= }} | ||
===Crystal structure of the human carboxypeptidase N (Kininase I) catalytic domain=== | |||
{{ABSTRACT_PUBMED_17157876}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN]] Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:[http://omim.org/entry/212070 212070]]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.<ref>PMID:12560874</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN]] Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017157876</ref><references group="xtra"/> | <ref group="xtra">PMID:017157876</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Lysine carboxypeptidase]] | [[Category: Lysine carboxypeptidase]] | ||