3twr: Difference between revisions

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-[[Image:3twr.png|left|200px]]
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 {{STRUCTURE_3twr|  PDB=3twr  |  SCENE=  }}
 ===Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human 3BP2===
+{{ABSTRACT_PUBMED_22153077}}
+==Disease==
+[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[http://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref><ref>PMID:12900899</ref><ref>PMID:14577811</ref>
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+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22153077}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref><ref>PMID:11739745</ref><ref>PMID:19759537</ref><ref>PMID:21478859</ref> [[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
-(as it appears on PubMed at http://www.pubmed.gov), where 22153077 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_22153077}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:022153077</ref><references group="xtra"/>
+<ref group="xtra">PMID:022153077</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Guettler, S.]]