2c0t: Difference between revisions
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==Overview== | ==Overview== | ||
We describe the identification, SAR, and pharmacology of the src-family | We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Transferred entry: 2 | [[Category: Transferred entry: 2 7.10 1 and 2 7.10 2]] | ||
[[Category: Borhani, D | [[Category: Borhani, D W.]] | ||
[[Category: Burchat, A.]] | [[Category: Burchat, A.]] | ||
[[Category: Calderwood, D | [[Category: Calderwood, D J.]] | ||
[[Category: Hirst, G | [[Category: Hirst, G C.]] | ||
[[Category: Li, B.]] | [[Category: Li, B.]] | ||
[[Category: Loew, A.]] | [[Category: Loew, A.]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:39 2008'' | ||
Revision as of 17:43, 21 February 2008
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SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
OverviewOverview
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
About this StructureAbout this Structure
2C0T is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Transferred entry: 2.7.10.1 and 2.7.10.2, with EC number 2.7.1.112 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Single protein
- Transferred entry: 2 7.10 1 and 2 7.10 2
- Borhani, D W.
- Burchat, A.
- Calderwood, D J.
- Hirst, G C.
- Li, B.
- Loew, A.
- CA
- L3G
- Alternative initiation
- Atp-binding
- Kinase
- Lipoprotein
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphorylation
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase