IgA: Difference between revisions

|<scene name='Rebecca_Martin/Sandbox1/Iga1_overview/1'>IgA1</scene>  

<scene name='Rebecca_Martin/Sandbox1/Iga1_hinge_ser_thr/1'>Potential Sites of O-linked Glycosylation (5 residues per hinge glycosylated)</scene> Protect from proteases and increase hinge rigidity. Note the extended hinge region of 23 amino acids, extending IgA1's antigenic reach.

<scene name='Rebecca_Martin/Sandbox1/Iga1_hinge_proline/1'>Hinge Prolines</scene> Increase hinge rigidity.

<scene name='Rebecca_Martin/Sandbox1/Iga1_n_glycos/2'>N-glycosylated residues</scene> Protect from proteases and increase hinge rigidity.

<scene name='Rebecca_Martin/Sandbox1/Iga1_j_chain/1'>J chain</scene>

<scene name='Rebecca_Martin/Sandbox1/Iga2_hinge_length/1'>Hinge length</scene> 10 amino acids in length

<scene name='Rebecca_Martin/Sandbox1/Iga2_hinge_length/1'>Hinge glycosylation</scene> Protect from proteases and increase hinge rigidity.

<scene name='Rebecca_Martin/Sandbox1/Iga2_hinge_proline/1'>Hinge Proline</scene> Increase hinge rigidity

<scene name='Rebecca_Martin/Sandbox1/Iga2_j_chain/1'>J chain</scene>

<scene name='Rebecca_Martin/Sandbox1/Siga1/1'>Secretory IgA2</scene> nonplanar (fab fragments not aligned with Fc portion)

|<scene name='Rebecca_Martin/Sandbox1/Igg_y_shape/1'>IgG</scene> Y shaped, with an intermediate length hinge region.

<scene name='Rebecca_Martin/Sandbox1/Igg_disulfides/1'>IgG: disulfide bonds connecting the heavy and light chains</scene>

<scene name='Rebecca_Martin/Sandbox1/Igg_glycines/1'>IgG: glycines (black)</scene> increase hinge flexibility. There are no proline residues in IgG's hinge region.

<scene name='Rebecca_Martin/Sandbox1/Igg_mutant/1'>IgG with hinge deletion</scene> (missing one fab fragment. Note the T-shape. Compare with IgA2.

<scene name='Rebecca_Martin/Sandbox1/Igg_mutant_no_disulfie/1'>Lack of a disulfide bond between heavy and light chains in above IgG

<scene name='Rebecca_Martin/Sandbox1/Igm/1'>IgM</scene>

<scene name='Rebecca_Martin/Sandbox1/Igd/1'>IgD</scene> Hinge region is 64 amino acids in length. Note similarity to IgA1.