2bfq: Difference between revisions
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==Overview== | ==Overview== | ||
The ADP-ribosylation of proteins is an important post-translational | The ADP-ribosylation of proteins is an important post-translational modification that occurs in a variety of biological processes, including DNA repair, transcription, chromatin biology and long-term memory formation. Yet no protein modules are known that specifically recognize the ADP-ribose nucleotide. We provide biochemical and structural evidence that macro domains are high-affinity ADP-ribose binding modules. Our structural analysis reveals a conserved ligand binding pocket among the macro domain fold. Consistently, distinct human macro domains retain their ability to bind ADP-ribose. In addition, some macro domain proteins also recognize poly-ADP-ribose as a ligand. Our data suggest an important role for proteins containing macro domains in the biology of ADP-ribose. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Archaeoglobus fulgidus]] | [[Category: Archaeoglobus fulgidus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Allen, M | [[Category: Allen, M D.]] | ||
[[Category: Buhecha, H | [[Category: Buhecha, H R.]] | ||
[[Category: Bycroft, M.]] | [[Category: Bycroft, M.]] | ||
[[Category: Karras, G | [[Category: Karras, G I.]] | ||
[[Category: Ladurner, A | [[Category: Ladurner, A G.]] | ||
[[Category: Pugieux, C.]] | [[Category: Pugieux, C.]] | ||
[[Category: Sait, F.]] | [[Category: Sait, F.]] | ||
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[[Category: nucleotide]] | [[Category: nucleotide]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:37:20 2008'' | ||