2bct: Difference between revisions
New page: left|200px<br /><applet load="2bct" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bct, resolution 2.9Å" /> '''THE ARMADILLO REPEAT ... |
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[[Image:2bct.gif|left|200px]]<br /><applet load="2bct" size=" | [[Image:2bct.gif|left|200px]]<br /><applet load="2bct" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2bct, resolution 2.9Å" /> | caption="2bct, resolution 2.9Å" /> | ||
'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''<br /> | '''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''<br /> | ||
==Overview== | ==Overview== | ||
Beta-catenin is essential for cadherin-based cell adhesion and | Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. | ||
==About this Structure== | ==About this Structure== | ||
2BCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | 2BCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Huber, A | [[Category: Huber, A H.]] | ||
[[Category: Nelson, W | [[Category: Nelson, W J.]] | ||
[[Category: Weis, W | [[Category: Weis, W I.]] | ||
[[Category: armadillo repeat]] | [[Category: armadillo repeat]] | ||
[[Category: beta-catenin]] | [[Category: beta-catenin]] | ||
[[Category: structural protein]] | [[Category: structural protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:36:32 2008'' | ||
Revision as of 17:36, 21 February 2008
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THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN
OverviewOverview
Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.
About this StructureAbout this Structure
2BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899
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