2b52: Difference between revisions

Revision as of 17:34, 21 February 2008

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562

OverviewOverview

New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.

About this StructureAbout this Structure

2B52 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.

ReferenceReference

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3., Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA, Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6. PMID:14698155

Page seeded by OCA on Thu Feb 21 16:34:14 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:2b52.gif|left|200px]]<br />
+[[Image:2b52.gif|left|200px]]<br /><applet load="2b52" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2b52" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2b52, resolution 1.88&Aring;" />
 '''Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562'''<br />
 ==Overview==
-New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have, been disclosed. The most promising compounds are nanomolar enzyme, inhibitors with excellent activity against tumor cells. The most advanced, compound retains cell culture activity even in the presence of human serum, proteins. The most advanced compound did not kill the normal fibroblast, line AG1523.
+New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.
 ==About this Structure==
-B52 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with D42 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2B52 OCA].
+B52 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=D42:'>D42</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B52 OCA].
 ==Reference==
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 [[Category: protein kinase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:58:43 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:14 2008''