Growth factor receptor-bound protein: Difference between revisions
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==3D structures of Grb2== | ==3D structures of Grb2== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1ghu]] – hGRB2 SH2 domain (mutant) – human<br /> | [[1ghu]] – hGRB2 SH2 domain (mutant) – human<br /> | ||
Revision as of 11:53, 10 March 2013
<StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)' scene=>
Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.
3D structures of Grb23D structures of Grb2
Updated on 10-March-2013
1ghu – hGRB2 SH2 domain (mutant) – human
1fhs, 1jyu, 2aoa, 2h46 - hGRB2 SH2 domain
2vvk, 2vwf, 2w0z - hGRB2 SH3 domain
1tze, 1bmb, 1bm2, 1zfp, 1qg1, 1jyq, 1jyr, 2aob, 2h5k, 2huw, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8n, 3s8o - hGRB2 SH2 domain + phosphotyrosyl peptide
1x0n - hGRB2 SH2 domain + inhibitor - NMR
1cj1 - hGRB2 SH2 domain + phosphotyrosyl derivative
1gbq, 2gbq, 3gbq, 4gbq, 1aze - GRB2 SH3 domain + SOS-1 peptide – NMR
1io6, 1h3h - GRB2 SH3 domain + ligand peptide – NMR