Ferritin

File:2jd73.png

Crystal structure of ferritin from Pyrococcs Furiousus (2jd7)

spinqualitylabelsall models Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus, 2jd7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL). Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity. Thioferritin (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site. Another iron storing protein is the DNA-binding Protein of Starved cells (Dps). MrgA – another iron storage protein - belongs to the Dps family.

3D Structures of Ferritin3D Structures of Ferritin

Updated on 07-March-2013

FerritinFerritin

2jd6, 2jd7 – PfFR - Pyrococcus furiosus
2jd8 – PfFR+Zn
3kxu – hFR (mutant) – human
3hx2, 3hx5, 3hx7, 1fha - hFR
3a68 – soFR from gene SferH4 – soybean
3a9q - soFR from gene SferH4 (mutant)
3egm, 3bvf, 3bvi, 3bvk, 3bvl – HpFR – Heliobacter pylori
3e6s - PnFR – Pseudo-nitzschia
1z4a, 1vlg – FR – Thermotoga maritime
1s3q, 1sq3, 3kx9 – FR – Archaeoglubus fulgidus
1krq – FR – Campylobacter jejuni
1eum - EcFR – Escherichia coli
1qgh – LiFR - Listeria innocua
1mfr, 1bg7, 3ka3, 3ka4, 3rbc, 3re7, 3rgd – bFR - Bullfrog
3ka6, 3ka8, 3ka9 – bFR (mutant)+Co
3se1, 3sh6, 3shx - bFR (mutant) + Mg
3qz3 - VcFR – Vibrio cholerae
3vnx – FR – Ulva pertusa

Ferritin light chain (FTL)Ferritin light chain (FTL)

1lb3, 1h96 – FTL – mouse
1rcc, 1rcd, 1rci – bFTL+tartrate+Mg
1rce, 1rcg - bFTL+tartrate+Mn
3noz, 3np0, 3np2, 3o7r – hoFTL (mutant) - horse
3o7s, 3u90 - hoFTL
3rav, 3rd0 – hoFTL + barbiturate

Ferritin heavy chain (FTH)Ferritin heavy chain (FTH)

2z6m, 1r03, 2fha, 3ajo – hFTH
3ajp, 3ajq - hFTH (mutant)
2z6o – FTH – Trichoplusia ni

apo-ferritin (apo-FR)apo-ferritin (apo-FR)

2x17 – apo-PfFR+Ag
3h7g – apo-hoFR+Au
1hrs - apo-hoFR+protoporphyrin
3bve – apo-HpFR
3e6r – apo-PnFR
2clu, 2cn6 - apo-hFR (mutant)+Zn

apo-ferritin light chain (apo-FTL)apo-ferritin light chain (apo-FTL)

2zg7, 2z5p, 2z5q, 2z5r, 3fi6, 3af7 – apo-hoFTL+Pd
2zg8, 2zg9, 3af8, 3af9 - apo-hoFTL (mutant)+Pd
3f33, 3f34, 3f35, 3f36, 3f37, 3f38, 3f39 - apo-hoFTL+phenols
2v2i, 2v2j - apo-hoFTL+haemin
2gyd - apo-hoFTL+diaziflurane
1xz1 - apo-hoFTL+halothane
1xz3 - apo-hoFTL+isoflurane
1gwg - apo-hoFTL+I3
2v2l, 2v2m, 2v2n, 2v2o, 2v2p, 2v2r, 2v2s - apo-hoFTL (mutant)+haemin
2za6, 2g4h, 1aew, 1dat, 1ier, 1ies, 3f32, 2zur, 2w0o - apo-hoFTL
2ffx, 2fg4, 2fg8 – apo-hFTL
4de6 - apo-hoFTL + arachidonic acid

apo-ferritin heavy chain (apo-FTH)apo-ferritin heavy chain (apo-FTH)

2za7, 2za8, 2cn7, 2chi, 2clu - apo-hoFTH (mutant)
2cei, 2cih, 2cn6, 2iu2 - apo-hoFTH (mutant)+Zn
3erz – apo-hFR+Hg
3es3 - apo-hFR+Au

Bacterioferritin (BFR)Bacterioferritin (BFR)

3gvy – BFR – Rhodobacter sphaeroides
1jgc - BFR – Rhodobacter capsulatus
1ji4 – BFR – Helicobacter pylori
1nf4, 1nf6, 1nfv – BFR – Desulfovibrio desulfuricans
3fvb – BmBFR - Brucelia melitensis
2fkz, 2fl0, 1sof – BFR – Azotobacrter vinelandii
2wtl, 3qb9, 3uof, 3uoi – BFR – Mycobacterium tuberculosis
3bkn - MsBFR – Mycobacterium smegmatis
3is7, 3is8, 3ise, 3isf, 3r2h, 3r2k, 3r2l, 3r2m, 3r2o, 3r2r, 3r2s – BFR – Pseudomonas aeruginosa
1bfr, 1bcf, 2htn, 2vxi, 3e1j, 3e1l, 3e1m, 3e1n, 3e1p, 3e1o, 3e1q, 2y3q – EcBFR
3e2c, 3ghq – EcBFR (mutant)
4am2, 4am4, 4am5 – BFR – Blastochloris viridis

Thioferritin (TFR)Thioferritin (TFR)

2vzb – TFR – Bacterioides fragilis

DNA-binding Protein of Starved cells (Dps)DNA-binding Protein of Starved cells (Dps)

3iq1 – VcDps
3ge4 – BmDps
2iy4 – Dps – Listeria monocytogenes
2bkc, 2bk6, 2bjy – LiDps (mutant)
2f7n – Dps – Deinococcus radiodurans
1tjo, 1tk6, 1tkp, 1tko, 1moj – Dps – Halobacterium salinarum
1o9r – Dps – Agrobacterium tumefaciens
1dps, 1f30, 1f33, 1jre – EcDps
1jts, 1l8h, 1l8i – EcDps (mutant)
2ux1, 2v15, 2xjm, 2xjn, 2xjo, 2xkq – Dps – Streptococcus suis
2yw6 – MsDps
3ak8, 3ak9 – Dps – Salmonella enterica
1n1q – Dps – Brevibacillus brevis
1vei, 1vel, 1veq, 2yw7 – MsDps
4dyu – Dpo – Yersinia pestis

MrgAMrgA

2chp – MrgA – Bacillus subtilis