C-JUN: Difference between revisions
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== Introduction == | == Introduction == | ||
The c-Jun protein is a member of transcription factors which consist of a basic region leucine zipper region <ref name="one"> PMID:8662824 </ref>. Originally identified by its homology to v-jun, the oncogene from the avian sarcomoa virus <ref name="four"> Bossy-Wetzel, E., Bakiri, L., Yaniv, M. (1997). Induction of apoptosis by the transcription factor c-Jun. EMO Journal. Vol.16;7. 1695-1709 </ref>. All these leucine zipper factors bind to DNA in one of two states: homo or heterodimers <ref name="two"> PMID:8662824 </ref>. In conjunction with the c-Fos protein these two proteins bind to specific regions of DNA strands. Together these two proteins form the c-fos/c-jun complex which help regulate cell growth and differentiation <ref name="one" />. The members of the jun and fos families include three Jun proteins and four Fos proteins (c-Jun, JunB, JunD,c-Fos, Fos-B, Fra1, and Fra2) <ref name="one" />. Regulation of the complex iteslf is done by interactions between the protein and DNA in addition to the protein-protein interactions between each of the leucine zipper domains <ref name="one" />. See [[Transcription and RNA Processing]]. | The '''c-Jun''' protein is a member of transcription factors which consist of a basic region leucine zipper region <ref name="one"> PMID:8662824 </ref>. Originally identified by its homology to v-jun, the oncogene from the avian sarcomoa virus <ref name="four"> Bossy-Wetzel, E., Bakiri, L., Yaniv, M. (1997). Induction of apoptosis by the transcription factor c-Jun. EMO Journal. Vol.16;7. 1695-1709 </ref>. All these leucine zipper factors bind to DNA in one of two states: homo or heterodimers <ref name="two"> PMID:8662824 </ref>. In conjunction with the c-Fos protein these two proteins bind to specific regions of DNA strands. Together these two proteins form the c-fos/c-jun complex which help regulate cell growth and differentiation <ref name="one" />. The members of the jun and fos families include three Jun proteins and four Fos proteins (c-Jun, JunB, JunD,c-Fos, Fos-B, Fra1, and Fra2) <ref name="one" />. Regulation of the complex iteslf is done by interactions between the protein and DNA in addition to the protein-protein interactions between each of the leucine zipper domains <ref name="one" />. See [[Transcription and RNA Processing]]. | ||
== Structure Overview == | == Structure Overview == | ||
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==3D structure of C-JUN== | ==3D structure of C-JUN== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1jun]] – hCJUN leucine zipper domain – human – NMR<br /> | [[1jun]] – hCJUN leucine zipper domain – human – NMR<br /> | ||