2ak4: Difference between revisions
New page: left|200px<br /> <applet load="2ak4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ak4, resolution 2.500Å" /> '''Crystal Structure ... |
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[[Image:2ak4.gif|left|200px]]<br /> | [[Image:2ak4.gif|left|200px]]<br /><applet load="2ak4" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="2ak4, resolution 2.500Å" /> | caption="2ak4, resolution 2.500Å" /> | ||
'''Crystal Structure of SB27 TCR in complex with HLA-B*3508-13mer peptide'''<br /> | '''Crystal Structure of SB27 TCR in complex with HLA-B*3508-13mer peptide'''<br /> | ||
==Overview== | ==Overview== | ||
Unusually long major histocompatibility complex (MHC) class I-restricted | Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still preserving MHC restriction, we have determined here the structure of a TCR in complex with HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was atypical of TCR-peptide-MHC class I interactions, being dominated at the interface by peptide-mediated interactions. The TCR assumed two distinct orientations, swiveling on top of the centrally bulged, rigid peptide such that only limited contacts were made with MHC class I. Although the TCR-peptide recognition resembled an antibody-antigen interaction, the TCR-MHC class I contacts defined a minimal 'generic footprint' of MHC-restriction. Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2AK4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with IOD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2AK4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=IOD:'>IOD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AK4 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Beddoe, T.]] | [[Category: Beddoe, T.]] | ||
[[Category: Borg, N | [[Category: Borg, N A.]] | ||
[[Category: Buckle, A | [[Category: Buckle, A M.]] | ||
[[Category: Burrows, J | [[Category: Burrows, J M.]] | ||
[[Category: Burrows, S | [[Category: Burrows, S R.]] | ||
[[Category: Clements, C | [[Category: Clements, C S.]] | ||
[[Category: Kjer-Nielsen, L.]] | [[Category: Kjer-Nielsen, L.]] | ||
[[Category: Konstenko, L.]] | [[Category: Konstenko, L.]] | ||
[[Category: McCluskey, J.]] | [[Category: McCluskey, J.]] | ||
[[Category: Miles, J | [[Category: Miles, J J.]] | ||
[[Category: Purcell, A | [[Category: Purcell, A W.]] | ||
[[Category: Rossjohn, J.]] | [[Category: Rossjohn, J.]] | ||
[[Category: Silins, S | [[Category: Silins, S L.]] | ||
[[Category: Tynan, F | [[Category: Tynan, F E.]] | ||
[[Category: Whisstock, J | [[Category: Whisstock, J C.]] | ||
[[Category: Wilce, M | [[Category: Wilce, M C.]] | ||
[[Category: IOD]] | [[Category: IOD]] | ||
[[Category: bulged epitopes]] | [[Category: bulged epitopes]] | ||
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[[Category: t cell receptor]] | [[Category: t cell receptor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:17 2008'' | ||
Revision as of 17:28, 21 February 2008
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Crystal Structure of SB27 TCR in complex with HLA-B*3508-13mer peptide
OverviewOverview
Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still preserving MHC restriction, we have determined here the structure of a TCR in complex with HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was atypical of TCR-peptide-MHC class I interactions, being dominated at the interface by peptide-mediated interactions. The TCR assumed two distinct orientations, swiveling on top of the centrally bulged, rigid peptide such that only limited contacts were made with MHC class I. Although the TCR-peptide recognition resembled an antibody-antigen interaction, the TCR-MHC class I contacts defined a minimal 'generic footprint' of MHC-restriction. Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction.
DiseaseDisease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this StructureAbout this Structure
2AK4 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide., Tynan FE, Burrows SR, Buckle AM, Clements CS, Borg NA, Miles JJ, Beddoe T, Whisstock JC, Wilce MC, Silins SL, Burrows JM, Kjer-Nielsen L, Kostenko L, Purcell AW, McCluskey J, Rossjohn J, Nat Immunol. 2005 Nov;6(11):1114-22. Epub 2005 Sep 25. PMID:16186824
Page seeded by OCA on Thu Feb 21 16:28:17 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Protein complex
- Beddoe, T.
- Borg, N A.
- Buckle, A M.
- Burrows, J M.
- Burrows, S R.
- Clements, C S.
- Kjer-Nielsen, L.
- Konstenko, L.
- McCluskey, J.
- Miles, J J.
- Purcell, A W.
- Rossjohn, J.
- Silins, S L.
- Tynan, F E.
- Whisstock, J C.
- Wilce, M C.
- IOD
- Bulged epitopes
- Pmhc/tcr complex
- T cell receptor