2ajl: Difference between revisions
New page: left|200px<br /> <applet load="2ajl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ajl, resolution 2.5Å" /> '''X-ray Structure of N... |
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[[Image:2ajl.gif|left|200px]]<br /> | [[Image:2ajl.gif|left|200px]]<br /><applet load="2ajl" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2ajl" size=" | |||
caption="2ajl, resolution 2.5Å" /> | caption="2ajl, resolution 2.5Å" /> | ||
'''X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor'''<br /> | '''X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor'''<br /> | ||
==Overview== | ==Overview== | ||
The discovery, SAR, and X-ray crystal structure of novel | The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported. | ||
==About this Structure== | ==About this Structure== | ||
2AJL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and JNH as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | 2AJL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=JNH:'>JNH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJL OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abad, M | [[Category: Abad, M C.]] | ||
[[Category: Baumann, C | [[Category: Baumann, C A.]] | ||
[[Category: Bayoumy, S | [[Category: Bayoumy, S S.]] | ||
[[Category: Crysler, C | [[Category: Crysler, C S.]] | ||
[[Category: DesJarlais, R | [[Category: DesJarlais, R L.]] | ||
[[Category: Kervinen, J.]] | [[Category: Kervinen, J.]] | ||
[[Category: Neeper, M | [[Category: Neeper, M P.]] | ||
[[Category: Ninan, N | [[Category: Ninan, N S.]] | ||
[[Category: Qiao, L.]] | [[Category: Qiao, L.]] | ||
[[Category: Spurlino, J | [[Category: Spurlino, J C.]] | ||
[[Category: JNH]] | [[Category: JNH]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:15 2008'' | ||
