2a11: Difference between revisions
New page: left|200px<br /><applet load="2a11" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a11, resolution 2.100Å" /> '''Crystal Structure o... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2a11.gif|left|200px]]<br /><applet load="2a11" size=" | [[Image:2a11.gif|left|200px]]<br /><applet load="2a11" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2a11, resolution 2.100Å" /> | caption="2a11, resolution 2.100Å" /> | ||
'''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis'''<br /> | '''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis'''<br /> | ||
==Overview== | ==Overview== | ||
RNase III enzymes are a highly conserved family of proteins that | RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs. | ||
==About this Structure== | ==About this Structure== | ||
2A11 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] Full crystallographic information is available from [http:// | 2A11 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A11 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Ribonuclease III]] | [[Category: Ribonuclease III]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Akey, D | [[Category: Akey, D L.]] | ||
[[Category: Berger, J | [[Category: Berger, J M.]] | ||
[[Category: XMTB, Mycobacterium | [[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)]] | [[Category: protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)]] | ||
| Line 22: | Line 22: | ||
[[Category: ribonuclease; rnase iii; nuclease domain; structural genomics]] | [[Category: ribonuclease; rnase iii; nuclease domain; structural genomics]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:22:38 2008'' | ||
Revision as of 17:22, 21 February 2008
|
Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis
OverviewOverview
RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.
About this StructureAbout this Structure
2A11 is a Single protein structure of sequence from Mycobacterium tuberculosis with as ligand. Active as Ribonuclease III, with EC number 3.1.26.3 Full crystallographic information is available from OCA.
ReferenceReference
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207
Page seeded by OCA on Thu Feb 21 16:22:38 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Mycobacterium tuberculosis
- Ribonuclease III
- Single protein
- Akey, D L.
- Berger, J M.
- XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.
- CA
- Protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)
- Psi
- Ribonuclease; rnase iii; nuclease domain; structural genomics