1zpb: Difference between revisions
New page: left|200px<br /> <applet load="1zpb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zpb, resolution 2.10Å" /> '''Crystal Structure o... |
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[[Image:1zpb.gif|left|200px]]<br /> | [[Image:1zpb.gif|left|200px]]<br /><applet load="1zpb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1zpb, resolution 2.10Å" /> | caption="1zpb, resolution 2.10Å" /> | ||
'''Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide'''<br /> | '''Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide'''<br /> | ||
==Overview== | ==Overview== | ||
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort | Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1ZPB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 995 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | 1ZPB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=995:'>995</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abdel-Meguid, S | [[Category: Abdel-Meguid, S S.]] | ||
[[Category: Babine, R | [[Category: Babine, R E.]] | ||
[[Category: Bannister, T | [[Category: Bannister, T D.]] | ||
[[Category: Bibbins, F.]] | [[Category: Bibbins, F.]] | ||
[[Category: Celatka, C | [[Category: Celatka, C A.]] | ||
[[Category: Deng, H.]] | [[Category: Deng, H.]] | ||
[[Category: Gorga, J.]] | [[Category: Gorga, J.]] | ||
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
[[Category: Lazarova, T | [[Category: Lazarova, T I.]] | ||
[[Category: Lin, J.]] | [[Category: Lin, J.]] | ||
[[Category: Meyers, H | [[Category: Meyers, H V.]] | ||
[[Category: Nagafuji, P.]] | [[Category: Nagafuji, P.]] | ||
[[Category: Pandey, P.]] | [[Category: Pandey, P.]] | ||
[[Category: Quinn, J.]] | [[Category: Quinn, J.]] | ||
[[Category: Rynkiewicz, M | [[Category: Rynkiewicz, M J.]] | ||
[[Category: Strickler, J | [[Category: Strickler, J E.]] | ||
[[Category: 995]] | [[Category: 995]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:49 2008'' | ||
Revision as of 17:17, 21 February 2008
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Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide
OverviewOverview
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.
DiseaseDisease
Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]
About this StructureAbout this Structure
1ZPB is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Coagulation factor XIa, with EC number 3.4.21.27 Full crystallographic information is available from OCA.
ReferenceReference
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine., Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE, Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:16524727
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