1zpc: Difference between revisions
New page: left|200px<br /> <applet load="1zpc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zpc, resolution 2.60Å" /> '''Crystal Structure o... |
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[[Image:1zpc.gif|left|200px]]<br /> | [[Image:1zpc.gif|left|200px]]<br /><applet load="1zpc" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1zpc, resolution 2.60Å" /> | caption="1zpc, resolution 2.60Å" /> | ||
'''Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide'''<br /> | '''Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide'''<br /> | ||
==Overview== | ==Overview== | ||
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort | Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1ZPC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 716 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | 1ZPC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=716:'>716</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPC OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abdel-Meguid, S | [[Category: Abdel-Meguid, S S.]] | ||
[[Category: Babine, R | [[Category: Babine, R E.]] | ||
[[Category: Bannister, T | [[Category: Bannister, T D.]] | ||
[[Category: Bibbins, F.]] | [[Category: Bibbins, F.]] | ||
[[Category: Celatka, C | [[Category: Celatka, C A.]] | ||
[[Category: Deng, H.]] | [[Category: Deng, H.]] | ||
[[Category: Gorga, J.]] | [[Category: Gorga, J.]] | ||
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
[[Category: Lazarova, T | [[Category: Lazarova, T I.]] | ||
[[Category: Lin, J.]] | [[Category: Lin, J.]] | ||
[[Category: Meyers, H | [[Category: Meyers, H V.]] | ||
[[Category: Nagafuji, P.]] | [[Category: Nagafuji, P.]] | ||
[[Category: Pandey, P.]] | [[Category: Pandey, P.]] | ||
[[Category: Quinn, J.]] | [[Category: Quinn, J.]] | ||
[[Category: Rynkiewicz, M | [[Category: Rynkiewicz, M J.]] | ||
[[Category: Strickler, J | [[Category: Strickler, J E.]] | ||
[[Category: 716]] | [[Category: 716]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:48 2008'' | ||
