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== 3D Structures of the Immunoglobulin ==
== 3D Structures of the Immunoglobulin ==


''Update June 2012''
''Update January 2013''


Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.
Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.
Line 127: Line 127:
[[8fab]] – hFab HIL<br />
[[8fab]] – hFab HIL<br />
[[1opg]] - hFab OPG2<br />
[[1opg]] - hFab OPG2<br />
[[3inu]] – hFab anti-Ebola<br />
[[3u6r]] – hFab anti-Hepatitis<br />
[[4gxv]] – hFab anti-influenza<br />
[[4fnl]] – hFab C05<br />
[[4fqh]] – hFab CR9114<br />
[[1om3]] – hFab 2G12<br />
[[1om3]] – hFab 2G12<br />
[[1aqk]] – hFab B7-15A2<br />
[[1aqk]] – hFab B7-15A2<br />
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[[3fzu]] – hFab igG1<br />
[[3fzu]] – hFab igG1<br />
[[3aaz]], [[3gje]] – hFab<br />
[[3aaz]], [[3gje]] – hFab<br />
[[3i75]] – mFab – mouse<br />
[[3iy2]] – mFab 6 – Cryo EM<br />
[[3iy3]] – mFab 8 – Cryo EM<br />
[[3iy4]] – mFab 15 – Cryo EM<br />
[[3iy5]] – mFab IggA2 – Cryo EM<br />
[[3iy6]] – rFab E – Cryo EM <br />
[[3iy7]] – rFab F – Cryo EM<br />
[[1jpt]] - hmFab D3H44<br />
[[1jpt]] - hmFab D3H44<br />
[[3mxv]] – mFab/hFab<br />
[[3mxv]] – mFab/hFab<br />
Line 170: Line 182:
[[2ipt]] – mFab PFA1<br />
[[2ipt]] – mFab PFA1<br />
[[1ct8]] – mFab 7C8<br />
[[1ct8]] – mFab 7C8<br />
[[1yeh]], [[1yec]], [[1yed]], [[1yee]], [[1eap]] - mFab catalytic<br />  
[[1yeh]], [[1yec]], [[1yed]], [[1yee]], [[1eap]], [[3bd3]], [[3bd4]], [[3bd5]]  - mFab catalytic<br />  
[[2iq9]], [[2iqa]] – mFab PFA2<br />
[[2iq9]], [[2iqa]] – mFab PFA2<br />
[[2w60]] – mFab ACC4<br />
[[2w60]] – mFab ACC4<br />
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[[2fat]] – mFab ATN-615<br />
[[2fat]] – mFab ATN-615<br />
[[1c12]] – mFab anti-traseolide<br />
[[1c12]] – mFab anti-traseolide<br />
[[3cfc]] – mFab EP2-19g2<br />
[[3cfe]] – mFab EP2-25c10<br />
[[3d69]] – mFab anti-factor IX<br />
[[3esu]] – mFab anthrax-neutralizing<br />
[[3esv]] – mFab M18 (mutant)<br />
[[3et9]] – mFab 1H (mutant)<br />
[[3qg7]] – mFab AP4-24H11<br />
[[3rvt]] – mFab 4C1<br />
[[3s62]] – mFab 2A8<br />
[[4gay]] – mFab AP[[3[[3
[[3cfj]], [[3cfk]] – hFab/mFab 34E4<br />
[[3cfj]], [[3cfk]] – hFab/mFab 34E4<br />
[[1bbj]] - hFab/mFab B72.3<br />
[[1bbj]] - hFab/mFab B72.3<br />
[[3mj8]] – AhFab HL4E10 – Armenian hamster<br />
[[3mj8]] – AhFab HL4E10 – Armenian hamster<br />
[[3r06]] – AhFab 2C11br />
[[3iy1]] – rFab B – rat<br />
[[3iy1]] – rFab B – rat<br />
[[1zan]] – rFab AD11<br />
[[1zan]] – rFab AD11<br />
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[[1rz7]], [[1rz8]], [[1rzf]], [[1rzg]], [[1rzi]] - hFab gp120-reactive anti-HIV<br />
[[1rz7]], [[1rz8]], [[1rzf]], [[1rzg]], [[1rzi]] - hFab gp120-reactive anti-HIV<br />
[[3mug]] - hFab PG16<br />
[[3mug]] - hFab PG16<br />
[[3juy]] – hFab 3B3<br />
[[3qeh]] – hFab N12-I15<br />
[[3tnn]] – hFab N5-I5<br />
[[3rpi]] – hFab 3BNC60<br />
[[3tnm]] – hFab A32<br />
[[3nz8]] – mFab 7C8 anti-HIV<br />
[[3nz8]] – mFab 7C8 anti-HIV<br />
[[3o6k]] – mFab 11H6H1 anti-HIV<br />
[[3o6k]] – mFab 11H6H1 anti-HIV<br />
[[3ntc]] – mFab KD-247 anti-HIV<br />
[[3ntc]] – mFab KD-247 anti-HIV<br />
[[3qeg]] – mFab N12-I2


===Fab: small molecule complex===
===Fab: small molecule complex===
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[[4fab]] – mFab 4-4-20 + fluorescin<br />
[[4fab]] – mFab 4-4-20 + fluorescin<br />
[[2mcp]] - mFab MCPC603 + phosphocholine<br />
[[2mcp]] - mFab MCPC603 + phosphocholine<br />
[[3cfb]], [[3cfd]] – mFab EP2-19g2 + stilbene hapten


===Fab: peptide complex===
===Fab: peptide complex===
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[[1frg]], [[1him]], [[1hin]], [[1ifh]] - mFab + hemagglutinin peptide<br />
[[1frg]], [[1him]], [[1hin]], [[1ifh]] - mFab + hemagglutinin peptide<br />
[[1tet]] – mFab + cholera toxin peptide<br />
[[1tet]] – mFab + cholera toxin peptide<br />
[[4gag]], [[4gaj]] – mFab + genome polyprotein peptide<br />
[[3bky]] – hFab/mFab + CD20 peptide<br />
[[3bky]] – hFab/mFab + CD20 peptide<br />


===Anti-HIV Fab: peptide complex===
===Anti-HIV Fab: peptide complex===


[[3egs]], [[3drt]], [[3drq]], [[3dro]], [[2fx7]], [[2fx8]], [[2fx9]], [[2cmr]], [[1tzg]], [[1tjg]] – hFab anti-HIV + gp41 peptide<br />
[[3egs]], [[3drt]], [[3drq]], [[3dro]], [[2fx7]], [[2fx8]], [[2fx9]], [[2cmr]], [[1tzg]], [[1tjg]], [[3mnw]], [[3moa]], [[3mob]], [[3mod]]– hFab anti-HIV + gp41 peptide<br />
[[3ghb]], [[3ghe]], [[3c2a]] - hFab anti-HIV + envelope glycoprotein peptide<br />
[[3ghb]], [[3ghe]], [[3c2a]] - hFab anti-HIV + envelope glycoprotein peptide<br />
[[3go1]] - hFab anti-HIV + envelope glycoprotein  gp160 peptide<br />
[[3go1]] - hFab anti-HIV + envelope glycoprotein  gp160 peptide<br />
[[3fn0]] - hFab Z13E1 anti-HIV + peptide<br />
[[3fn0]] - hFab Z13E1 anti-HIV + peptide<br />
[[2oqj]] – hFab 2G12 anti-HIV + peptide<br />
[[2oqj]] – hFab 2G12 anti-HIV + peptide<br />
[[2b0s]], [[2b1a]], [[2b1h]] - hFab anti-HIV + glycoprotein gp120 peptide<br />
[[2b0s]], [[2b1a]], [[2b1h]], [[3se8]], [[3se9]]  - hFab anti-HIV + glycoprotein gp120 peptide<br />
[[1nak]], [[2f58]], [[3f58]], [[1f58]], [[1acy]] - mFab anti-HIV + glycoprotein gp120 peptide<br />
[[1nak]], [[2f58]], [[3f58]], [[1f58]], [[1acy]] - mFab anti-HIV + glycoprotein gp120 peptide<br />
[[1ai1]], [[1ggi]] – mFab anti-HIV + V3 peptide<br />
[[1ai1]], [[1ggi]] – mFab anti-HIV + V3 peptide<br />
Line 298: Line 329:
===Fab: protein complex===  
===Fab: protein complex===  


[[3pjs]], [[3efd]], [[3eff]] – mFab + KcsA K+ channel<br />
[[3r1g]] – hFab + beta-secretase 1<br />
[[3r1g]] – hFab + beta-secretase 1<br />
[[3raj]] – mFab HB7 + CD38<br />
[[3raj]] – mFab HB7 + CD38<br />
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[[3b2u]], [[3b2v]] – hFab IMC-11F8 + EGFR<br />
[[3b2u]], [[3b2v]] – hFab IMC-11F8 + EGFR<br />
[[2r0k]], [[2r0l]] – hFab + HGFA<br />
[[2r0k]], [[2r0l]] – hFab + HGFA<br />
[[3ld8]] – CmFab + bifunctional arginine demethylase – ''Cricetulus migratorius''<br />
[[3ld8]], [[3ldb]] – AhFab + bifunctional arginine demethylase <br />
[[3be1]], [[3n85]], [[1n8z]] - hFab + ERBB-2<br />
[[3be1]], [[3n85]], [[1n8z]] - hFab + ERBB-2<br />
[[3kr3]] – hFab + IGF-II<br />
[[3kr3]] – hFab + IGF-II<br />
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[[3idx]], [[3idy]] - hFab B13 anti-HIV + gp120 core<br />
[[3idx]], [[3idy]] - hFab B13 anti-HIV + gp120 core<br />
[[2x7l]] – Fab anti-HIV + HIV REV<br />
[[2x7l]] – Fab anti-HIV + HIV REV<br />
[[3gbm]], [[3gbn]], [[3lzf]] - hFab + hemagglutinin<br />
[[3gbm]], [[3gbn]], [[3lzf]], [[3fku]], [[3sdy]], [[3ztj]], [[3ztn]], [[4fp8]], [[4fqi]], [[4fqj]], [[4fqk]], [[4fql]], [[4fqr]], [[4fqv]], [[4fqy]], [[4gxu]]- hFab + hemagglutinin<br />
[[3g6j]] – hFab + complement C3<br />
[[3g6j]] – hFab + complement C3<br />
[[2vxq]] – hFab + pollen allergen PHL<br />
[[2vxq]] – hFab + pollen allergen PHL<br />
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[[1za3]] - hFab YSD1 + TNF receptor<br />
[[1za3]] - hFab YSD1 + TNF receptor<br />
[[3l95]] – Fab + NRR1<br />
[[3l95]] – Fab + NRR1<br />
[[1uj3]] – hFab HATR-5 + tissue factor<br />
[[1uj3]], [[4dtg]] – hFab + tissue factor<br />
[[3lev]] – hFab 2F5 + RNA polymerase sigma factor<br />
[[3ru8]] – hFab B12 + epitope scaffold 2BODX43<br />
[[3skj]] – hFab + ephrin receptor<br />
[[3sob]] – hFab + LPR6<br />
[[3t2n]] – hFab + serine protease hepsin<br />
[[3ux9]] – hFab anti-interferon + interferon<br />
[[3vg9]] – hFab + adenosine receptor<br />
[[3vga]] – hFab + adenosine receptor (mutant)<br />
[[1jps]] - hmFab D3H44 + tissue factor<br />
[[1jps]] - hmFab D3H44 + tissue factor<br />
[[1ahw]] - mFab 5G9+ tissue factor<br />
[[1ahw]] - mFab 5G9+ tissue factor<br />
Line 359: Line 397:
[[3ivk]], [[2r8s]] – mFab + RNA<br />
[[3ivk]], [[2r8s]] – mFab + RNA<br />
[[2fr4]], [[1xf2]], [[1xf3]], [[1xf4]], [[1i8m]], [[1cbv]] – mFab + DNA<br />
[[2fr4]], [[1xf2]], [[1xf3]], [[1xf4]], [[1i8m]], [[1cbv]] – mFab + DNA<br />
[[1mhp]] – mFab  + integrin<br />
[[1mhp]], [[3q3g]], [[3qa3]] – mFab  + integrin<br />
[[3ab0]] – mFab + BCLA protein<br />
[[3etb]] – mFab M18 (mutant) + anthrax-protective antigen<br />
[[3f5w]], [[3pjs]], [[3efd]], [[3eff]] – mFab + KcsA K+ channel<br />
[[3stl]], [[3stz]] - mFab + KcsA K+ channel (mutant)<br />
[[3fmg]] – mFab + glycoprotein VP7<br />
[[3ve0]] - mFab + Ebola envelope glycoprotein<br />
[[4f9l]], [[4f9p]] – mFab anti-BTN3A1 + butyrophilin A1<br />
[[3k7u]], [[3k80]] – LgFab + MP18 RNA editing protein – Lama glama<br />
[[3mj9]] – AhFab HL4E10 + JAML <br />
[[3r08]] - AhFab 2C11 + CD3ε


===Fab: protein ternary complex===  
===Fab: protein ternary complex===  
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[[3jwd]], [[3jwo]] - hFab 48D anti-HIV + CD4 + gp120<br />
[[3jwd]], [[3jwo]] - hFab 48D anti-HIV + CD4 + gp120<br />
[[3d85]] - hFab 7G10 + IL-12 + IL-23<br />
[[3d85]] - hFab 7G10 + IL-12 + IL-23<br />
[[3bt2]] – hFab anti-UPAR + urokinase-type plasminogen activator + vitronectin<br />
[[3gjf]], [[3hae]] – hFab + β-2-microglobulin + MHC antigen + NYESO peptide<bt />
[[3gb7]], [[2p7t]], [[2h8p]], [[2hfe]], [[2atk]] - mFab + KcsA K+ channel + ion<br />
[[3gb7]], [[2p7t]], [[2h8p]], [[2hfe]], [[2atk]] - mFab + KcsA K+ channel + ion<br />
[[3or6]], [[3or7]], [[3ogc]], [[3fb7]], [[3f7v]], [[3f7y]], [[3fb5]], [[3fb6]], [[3fb8]], [[3iga]], [[2itc]], [[2itd]], [[2nlj]], [[2bob]], [[2boc]], [[1s5h]], [[1r3i]], [[1r3j]], [[1r3k]], [[1r3l]], [[1k4c]], [[1k4d]] - mFab + KcsA K+ channel (mutant) + ion<br />
[[3or6]], [[3or7]], [[3ogc]], [[3fb7]], [[3f7v]], [[3f7y]], [[3fb5]], [[3fb6]], [[3fb8]], [[3iga]], [[2itc]], [[2itd]], [[2nlj]], [[2bob]], [[2boc]], [[1s5h]], [[1r3i]], [[1r3j]], [[1r3k]], [[1r3l]], [[1k4c]], [[1k4d]], [[3hpl]] - mFab + KcsA K+ channel (mutant) + ion<br />
[[2fd6]] – mFab ATN-615 + urokinase-type plasminogen activator + urokinase plasminogen receptor<br />
[[2fd6]] – mFab ATN-615 + urokinase-type plasminogen activator + urokinase plasminogen receptor<br />
[[3v0a]] – LgFab + BONT/A1 + NTNH


===Full Immunoglobulin===
===Full Immunoglobulin===
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===Fc Fragments===
===Fc Fragments===


[[3dnk]] - hFc Igg1br />
[[1f6a]] -  hFc  IgE + high-affinity receptor Fc (ε) RI (α)<br />
[[1f6a]] -  hFc  IgE + high-affinity receptor Fc (ε) RI (α)<br />
[[1e4k]] - hFc Igg1 + Fc-γ-Riii Complex<br />
[[1e4k]] - hFc Igg1 + Fc-γ-Riii Complex<br />
[[1fp5]] - hFc IgE C ε 3-C ε 4<br />
[[1fp5]] - hFc IgE C ε 3-C ε 4<br />
===Fv Fragments===
[[3dur]], [[3dus]], [[3duu]], [[3dv4]], [[3dv6]] – mFv + Ig-like protein<br />
[[3h3b]] – mFv + ERBB2<br />
[[3hb3]] – mFv + cytochrome c oxidase subunit 1-beta


==References==
==References==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, David Canner, Wayne Decatur, Alexander Berchansky, Michal Harel, Mark Hoelzer
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