Antithrombin: Difference between revisions
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{{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin (beige) complex with thrombin heavy chain (pink), light chain (green) and heparin polysaccharide, [[1tb6]] }} | {{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin (beige) complex with thrombin heavy chain (pink), light chain (green) and heparin polysaccharide, [[1tb6]] }} | ||
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. | ||
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Revision as of 15:42, 17 January 2013
Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
3D structures of antithrombin3D structures of antithrombin
Updated January 2013
1att – AT-III – bovine
1e05 - hα-AT-III
1e04 – hβ-AT-III
1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)
Antithrombin binary complexesAntithrombin binary complexes
1azx, 1nq9, 3evj – hAT + heparin pentasaccharide
1e03 – hα-AT-III + heparin pentasaccharide
1dzh - hAT-III (mutant) + fluorescein
2gd4 - hAT-III (mutant) + coagulation factor X
1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide
Antithrombin ternary complexesAntithrombin ternary complexes
1sr5 - hAT-III + prothrombin + heparin heptasaccharide
1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide
2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide