1yw2: Difference between revisions
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New page: left|200px<br /><applet load="1yw2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yw2, resolution 2.01Å" /> '''Mutated Mus Musculus... |
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[[Image:1yw2.gif|left|200px]]<br /><applet load="1yw2" size=" | [[Image:1yw2.gif|left|200px]]<br /><applet load="1yw2" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1yw2, resolution 2.01Å" /> | caption="1yw2, resolution 2.01Å" /> | ||
'''Mutated Mus Musculus P38 Kinase (mP38)'''<br /> | '''Mutated Mus Musculus P38 Kinase (mP38)'''<br /> | ||
==Overview== | ==Overview== | ||
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis | 4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production. | ||
==About this Structure== | ==About this Structure== | ||
1YW2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with PGJ as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | 1YW2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=PGJ:'>PGJ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YW2 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bookland, R | [[Category: Bookland, R G.]] | ||
[[Category: Brugel, T | [[Category: Brugel, T A.]] | ||
[[Category: Clark, M | [[Category: Clark, M P.]] | ||
[[Category: De, B.]] | [[Category: De, B.]] | ||
[[Category: Djung, J | [[Category: Djung, J F.]] | ||
[[Category: Golebiowski, A.]] | [[Category: Golebiowski, A.]] | ||
[[Category: Hsieh, L | [[Category: Hsieh, L C.]] | ||
[[Category: Janusz, M | [[Category: Janusz, M J.]] | ||
[[Category: Laufersweiler, M | [[Category: Laufersweiler, M J.]] | ||
[[Category: Laughlin, S | [[Category: Laughlin, S K.]] | ||
[[Category: Mekel, M | [[Category: Mekel, M J.]] | ||
[[Category: Sabat, M.]] | [[Category: Sabat, M.]] | ||
[[Category: Townes, J | [[Category: Townes, J A.]] | ||
[[Category: Vanrens, J | [[Category: Vanrens, J C.]] | ||
[[Category: Walter, R | [[Category: Walter, R L.]] | ||
[[Category: Xu, S | [[Category: Xu, S C.]] | ||
[[Category: PGJ]] | [[Category: PGJ]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:47 2008'' | ||
Revision as of 17:09, 21 February 2008
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Mutated Mus Musculus P38 Kinase (mP38)
OverviewOverview
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production.
About this StructureAbout this Structure
1YW2 is a Single protein structure of sequence from Mus musculus with as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
ReferenceReference
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production., Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2399-403. PMID:15837333
Page seeded by OCA on Thu Feb 21 16:09:47 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Mus musculus
- Non-specific serine/threonine protein kinase
- Single protein
- Bookland, R G.
- Brugel, T A.
- Clark, M P.
- De, B.
- Djung, J F.
- Golebiowski, A.
- Hsieh, L C.
- Janusz, M J.
- Laufersweiler, M J.
- Laughlin, S K.
- Mekel, M J.
- Sabat, M.
- Townes, J A.
- Vanrens, J C.
- Walter, R L.
- Xu, S C.
- PGJ
- Transferase