Group:MUZIC:Tritopodin: Difference between revisions

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==~~TRITOPODIN~~==

==Introduction==

Tritopodin is the third member (besides myopodin and synaptopodin) of the podin family proteins and is codified by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Trotopodin is also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>. Tritopodin share 33% of homology in the Aminoacid sequence with Myopodin and 30% with Synaptopodin <ref> PMID:9314539 </ref>, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 3 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb) <ref> PMID:20215401 </ref> and .

Tritopodin is the third member (besides myopodin and synaptopodin) of the podin family proteins and is codified by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Trotopodin is also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>.

==Sequence Annotation==

Tritopodin share 33% of homology in the Aminoacid sequence with Myopodin and 30% with Synaptopodin <ref> PMID:9314539 </ref>, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 3 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb) <ref> PMID:20215401 </ref> and .

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Tritopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin, verify by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes <ref> PMID:20215401 </ref>.

==Pathology==

==References==

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 <Structure load='Trit_pdz_pred.pdb' size='400' frame='true' align='right' caption='Prediction of the PDZ binding domain of Tritopodin . Lambert et al. ESyPred3D:Prediction of Proteins 3D structures. Bioinformatics 2002)' scene='Insert optional scene name here' />
-==TRITOPODIN==
+==Introduction==
-Tritopodin is the third member (besides myopodin and synaptopodin) of the podin family proteins and is codified by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member  of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Trotopodin is also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>. Tritopodin share 33% of homology in the Aminoacid sequence with Myopodin and 30% with Synaptopodin <ref> PMID:9314539 </ref>, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 3 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb) <ref> PMID:20215401 </ref> and .
+Tritopodin is the third member (besides myopodin and synaptopodin) of the podin family proteins and is codified by the gene ''SYNPO2L''[http://www.uniprot.org/uniprot/Q9H987]. Tritopodin has been revealed by database searches, and since it is the third member  of the podin family of proteins with extended sequence similarity, was named ‘‘tritopodin’’. Trotopodin is also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein) and is found in heart and skeletal muscle tissue <ref> PMID:19151983 </ref>.
+==Sequence Annotation==
+Tritopodin share 33% of homology in the Aminoacid sequence with Myopodin and 30% with Synaptopodin <ref> PMID:9314539 </ref>, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 3 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4, from which derives two proteins variants of 140kDa (mCHAPa) and 110kDa (mCHAPb) <ref> PMID:20215401 </ref> and .
@@ Line 14: / Line 17: @@
 Tritopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin, verify by CoIPs and yeast two-hybrid assays <ref> PMID:20554076 </ref>. Adult skeletal and heart tissue shows the colocalization from mCHAP with α-actinin in the sarcomeric Z-disc and in the nucleus in embrional Cardiomyocytes <ref> PMID:20215401 </ref>.
+==Pathology==
 ==References==
 <references/>