1h8p: Difference between revisions
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[[Category: phosphorylcholine-binding protein]] | [[Category: phosphorylcholine-binding protein]] | ||
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Revision as of 16:27, 30 October 2007
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BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE
OverviewOverview
Bovine seminal plasma PDC-109 binds to sperm surface choline lipids and, promotes sperm capacitation by stimulating the efflux of cholesterol and, phospholipids. The structure of PDC-109 with bound phosphorylcholine was, solved using MAD data of a single platinum site. Its two globular (40 x 50, x 20 A(3)) Fn2 domains are linked and clustered by a short polypeptide., The choline binding sites lie at the same face of the molecule., Phosphorylcholine binds to the Fn2 domains through a cation-pi interaction, between the quaternary ammonium group and a core tryptophan, plus hydrogen, bonding between hydroxyls of exposed tyrosines and the phosphate group., The structure of the PDC-109-oPC complex provides a structural ground for, the sperm membrane-coating mechanism underlying PDC-109-induced, ... [(full description)]
About this StructureAbout this Structure
1H8P is a [Single protein] structure of sequence from [Bos taurus] with PC as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:11937055
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