1xuo: Difference between revisions
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==Overview== | ==Overview== | ||
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 | 1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:59 2008'' | ||
Revision as of 16:59, 21 February 2008
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X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution
OverviewOverview
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.
About this StructureAbout this Structure
1XUO is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1., Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G, Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. PMID:15686945
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