1xp6: Difference between revisions
New page: left|200px<br /> <applet load="1xp6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xp6, resolution 1.70Å" /> '''HUMAN ESTROGEN RECE... |
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[[Image:1xp6.gif|left|200px]]<br /> | [[Image:1xp6.gif|left|200px]]<br /><applet load="1xp6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1xp6" size=" | |||
caption="1xp6, resolution 1.70Å" /> | caption="1xp6, resolution 1.70Å" /> | ||
'''HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16'''<br /> | '''HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16'''<br /> | ||
==Overview== | ==Overview== | ||
A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side | A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1XP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AIU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1XP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AIU:'>AIU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XP6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fitzgerald, P | [[Category: Fitzgerald, P M.D.]] | ||
[[Category: Sharma, N.]] | [[Category: Sharma, N.]] | ||
[[Category: AIU]] | [[Category: AIU]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:57:08 2008'' | ||
Revision as of 16:57, 21 February 2008
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16
OverviewOverview
A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
DiseaseDisease
Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[133430], Breast cancer OMIM:[133430], Estrogen resistance OMIM:[133430], HDL response to hormone replacement, augmented OMIM:[133430], Migraine, susceptibility to OMIM:[133430], Myocardial infarction, susceptibility to OMIM:[133430]
About this StructureAbout this Structure
1XP6 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers., Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML, Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. PMID:15582421
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