3cd8: Difference between revisions

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{{Seed}}
[[Image:3cd8.png|left|200px]]
[[Image:3cd8.png|left|200px]]


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{{STRUCTURE_3cd8|  PDB=3cd8  |  SCENE=  }}  
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===X-ray Structure of c-Met with triazolopyridazine Inhibitor.===
===X-ray Structure of c-Met with triazolopyridazine Inhibitor.===


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{{ABSTRACT_PUBMED_18426196}}
{{ABSTRACT_PUBMED_18426196}}
==Disease==
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]]


==About this Structure==
==About this Structure==
3CD8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CD8 OCA].  
[[3cd8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CD8 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:18426196</ref><references group="xtra"/>
<ref group="xtra">PMID:018426196</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Triazolopyridazine]]
[[Category: Triazolopyridazine]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:53:03 2009''

Revision as of 20:55, 7 January 2013

File:3cd8.png

Template:STRUCTURE 3cd8

X-ray Structure of c-Met with triazolopyridazine Inhibitor.X-ray Structure of c-Met with triazolopyridazine Inhibitor.

Template:ABSTRACT PUBMED 18426196

About this StructureAbout this Structure

3cd8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Albrecht BK, Harmange JC, Bauer D, Berry L, Bode C, Boezio AA, Chen A, Choquette D, Dussault I, Fridrich C, Hirai S, Hoffman D, Larrow JF, Kaplan-Lefko P, Lin J, Lohman J, Long AM, Moriguchi J, O'Connor A, Potashman MH, Reese M, Rex K, Siegmund A, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Bellon SF. Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase. J Med Chem. 2008 May 22;51(10):2879-82. Epub 2008 Apr 22. PMID:18426196 doi:10.1021/jm800043g

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