1wzy: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 ==Overview==
-A series of pyrazolopyridazine compounds were briefly investigated as ERK2, inhibitors. The crystal structure of ERK2 complexed with an allyl, derivative was determined. The compound induces structural change, including movement of the glycine-rich loop and peptide flip between, Met108-Glu109. As a result, the newly formed subsite can recognize small, hydrophobic substituents but not hydrophilic ones.
+A series of pyrazolopyridazine compounds were briefly investigated as ERK2 inhibitors. The crystal structure of ERK2 complexed with an allyl derivative was determined. The compound induces structural change including movement of the glycine-rich loop and peptide flip between Met108-Glu109. As a result, the newly formed subsite can recognize small hydrophobic substituents but not hydrophilic ones.
 ==Disease==
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 [[Category: kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:08:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:49:45 2008''