2fvc: Difference between revisions
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[[Image:2fvc.png|left|200px]] | [[Image:2fvc.png|left|200px]] | ||
{{STRUCTURE_2fvc| PDB=2fvc | SCENE= }} | {{STRUCTURE_2fvc| PDB=2fvc | SCENE= }} | ||
===Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone=== | ===Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone=== | ||
{{ABSTRACT_PUBMED_16451063}} | {{ABSTRACT_PUBMED_16451063}} | ||
==About this Structure== | ==About this Structure== | ||
[[2fvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVC OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:016451063</ref><references group="xtra"/> | ||
[[Category: Hepatitis c virus subtype 1b]] | [[Category: Hepatitis c virus subtype 1b]] | ||
[[Category: Concha, N O.]] | [[Category: Concha, N O.]] | ||
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[[Category: Thiadiazin inhibitor]] | [[Category: Thiadiazin inhibitor]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 15:53, 7 January 2013
Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinoneCrystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone
Template:ABSTRACT PUBMED 16451063
About this StructureAbout this Structure
2fvc is a 2 chain structure with sequence from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ. 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones , potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem. 2006 Feb 9;49(3):971-83. PMID:16451063 doi:10.1021/jm050855s