1w2k: Difference between revisions
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==Overview== | ==Overview== | ||
Proof of concept experiments have shown that tissue factor/factor VIIa | Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling. | ||
==Disease== | ==Disease== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Ackermann, J.]] | [[Category: Ackermann, J.]] | ||
[[Category: Arcy, A | [[Category: Arcy, A D.]] | ||
[[Category: Banner, D | [[Category: Banner, D W.]] | ||
[[Category: Groebke-Zbinden, K.]] | [[Category: Groebke-Zbinden, K.]] | ||
[[Category: Ji, Y.]] | [[Category: Ji, Y.]] | ||
[[Category: Kirchhofer, D.]] | [[Category: Kirchhofer, D.]] | ||
[[Category: Tschopp, T | [[Category: Tschopp, T B.]] | ||
[[Category: Wallbaum, S.]] | [[Category: Wallbaum, S.]] | ||
[[Category: Weber, L.]] | [[Category: Weber, L.]] | ||
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[[Category: vitamin k]] | [[Category: vitamin k]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:45 2008'' | ||
Revision as of 16:39, 21 February 2008
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TF7A_4380 COMPLEX
OverviewOverview
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
DiseaseDisease
Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this StructureAbout this Structure
1W2K is a Protein complex structure of sequences from Homo sapiens with , , , and as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
Page seeded by OCA on Thu Feb 21 15:39:45 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Coagulation factor VIIa
- Homo sapiens
- Protein complex
- Ackermann, J.
- Arcy, A D.
- Banner, D W.
- Groebke-Zbinden, K.
- Ji, Y.
- Kirchhofer, D.
- Tschopp, T B.
- Wallbaum, S.
- Weber, L.
- 380
- BGC
- CA
- CAC
- FUC
- Blood coagulation
- Calcium-binding
- Co-factor
- Coagulation
- Enzyme complex
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Plasma
- Serine protease
- Vitamin k