2o8d: Difference between revisions

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{{Seed}}
[[Image:2o8d.png|left|200px]]
[[Image:2o8d.png|left|200px]]


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{{STRUCTURE_2o8d|  PDB=2o8d  |  SCENE=  }}  
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===human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair===
===human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair===


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{{ABSTRACT_PUBMED_17531815}}
{{ABSTRACT_PUBMED_17531815}}
==Disease==
Known disease associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Mismatch repair cancer syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Muir-Torre syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]]


==About this Structure==
==About this Structure==
2O8D is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8D OCA].  
[[2o8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8D OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:17531815</ref><references group="xtra"/>
<ref group="xtra">PMID:017531815</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Beese, L S.]]
[[Category: Beese, L S.]]
Line 34: Line 19:
[[Category: Warren, J J.]]
[[Category: Warren, J J.]]
[[Category: Cancer]]
[[Category: Cancer]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna damage response]]
[[Category: Dna damage response]]
[[Category: Dna mismatch repair]]
[[Category: Dna mismatch repair]]
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Somatic hypermutation]]
[[Category: Somatic hypermutation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:35:05 2009''

Revision as of 13:59, 7 January 2013

File:2o8d.png

Template:STRUCTURE 2o8d

human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispairhuman MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair

Template:ABSTRACT PUBMED 17531815

About this StructureAbout this Structure

2o8d is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS. Structure of the human MutSalpha DNA lesion recognition complex. Mol Cell. 2007 May 25;26(4):579-92. PMID:17531815 doi:10.1016/j.molcel.2007.04.018

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