1gue: Difference between revisions
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Revision as of 16:14, 30 October 2007
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SENSORY RHODOPSIN II
OverviewOverview
Sensory rhodopsins are the primary receptors of vision in animals and, phototaxis in microorganisms. Light triggers the rapid isomerization of a, buried retinal chromophore, which the protein both accommodates and, amplifies into the larger structural rearrangements required for, signaling. We trapped an early intermediate of the photocycle of sensory, rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and, determined its X-ray structure to 2.3 A resolution. The observed, structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's, beta-ionone ring undergoing a prominent movement. Comparison with the, early structural rearrangements of bacteriorhodopsin illustrates how, modifications in the retinal ... [(full description)]
About this StructureAbout this Structure
1GUE is a [Single protein] structure of sequence from [Natronomonas pharaonis] with CL and RET as [ligands]. Structure known Active Site: RET. Full crystallographic information is available from [OCA].
ReferenceReference
Early structural rearrangements in the photocycle of an integral membrane sensory receptor., Edman K, Royant A, Nollert P, Maxwell CA, Pebay-Peyroula E, Navarro J, Neutze R, Landau EM, Structure. 2002 Apr;10(4):473-82. PMID:11937052
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