2b7a: Difference between revisions

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{{Seed}}
[[Image:2b7a.png|left|200px]]
[[Image:2b7a.png|left|200px]]


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{{STRUCTURE_2b7a|  PDB=2b7a  |  SCENE=  }}  
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===The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor===
===The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor===


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{{ABSTRACT_PUBMED_16174768}}
{{ABSTRACT_PUBMED_16174768}}
==Disease==
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]]


==About this Structure==
==About this Structure==
2B7A is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7A OCA].  
[[2b7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7A OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:16174768</ref><references group="xtra"/>
<ref group="xtra">PMID:016174768</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Transferase]]
[[Category: Transferase]]
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[[Category: Wilks, A F.]]
[[Category: Wilks, A F.]]
[[Category: Kinase]]
[[Category: Kinase]]
 
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:52:11 2009''

Revision as of 12:58, 6 January 2013

File:2b7a.png

Template:STRUCTURE 2b7a

The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitorThe structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Template:ABSTRACT PUBMED 16174768

About this StructureAbout this Structure

2b7a is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, Walter M, Burns CJ, Treutlein H, Wilks AF, Rossjohn J. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood. 2006 Jan 1;107(1):176-83. Epub 2005 Sep 20. PMID:16174768 doi:http://dx.doi.org/10.1182/blood-2005-06-2413

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