Sandbox Reserved 703: Difference between revisions
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HPBP consists of 376 residues with a predicted molecular mass of 38.4 kDa. It contains two similar global domains, connected by a hinge. Each is constituted by a five-stranded <scene name='Sandbox_Reserved_703/Beta_sheets/1'>β sheet</scene> core (three parallel β strands followed by two antiparallel β strands) flanked by <scene name='Sandbox_Reserved_703/Alpha_helices/1'>α helices</scene>. There are two disulfide bridges (<scene name='Sandbox_Reserved_703/Disulfid_bond1/1'>C113-C158</scene>, <scene name='Sandbox_Reserved_703/Disulfid_bond2/1'>C306-C369</scene>). | HPBP consists of 376 residues with a predicted molecular mass of 38.4 kDa. It contains two similar global domains, connected by a hinge. Each is constituted by a five-stranded <scene name='Sandbox_Reserved_703/Beta_sheets/1'>β sheet</scene> core (three parallel β strands followed by two antiparallel β strands) flanked by <scene name='Sandbox_Reserved_703/Alpha_helices/1'>α helices</scene>. There are two disulfide bridges (<scene name='Sandbox_Reserved_703/Disulfid_bond1/1'>C113-C158</scene>, <scene name='Sandbox_Reserved_703/Disulfid_bond2/1'>C306-C369</scene>). | ||
The <scene name='Sandbox_Reserved_703/ | The <scene name='Sandbox_Reserved_703/Active_center1/1'>active site</scene> is similar to other phosphate SBPs. | ||
The surface of the binding pocket is negative. | The surface of the binding pocket is negative. | ||
In total, 8 residues and 13 hydrogen bonds are involved in the binding of the substrate creating a rich network. 12 bonds are formed by dipolar donor groups with <scene name='Sandbox_Reserved_703/6n_backbones/1'>6 backbones NHs</scene> (T8, L9, S32, S144, G145, T146) mostly located at the end of 3 helices, 2 NH side chains from R140 and 4 from side chains OHs (T8, S32, S144, T146) | In total, 8 residues and 13 hydrogen bonds are involved in the binding of the substrate creating a rich network. 12 bonds are formed by dipolar donor groups with <scene name='Sandbox_Reserved_703/6n_backbones/1'>6 backbones NHs</scene> (T8, L9, S32, S144, G145, T146) mostly located at the end of 3 helices, 2 NH side chains from R140 and 4 from side chains OHs (T8, S32, S144, T146) | ||