Sandbox Reserved 713: Difference between revisions
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An Alzheimer disease is responsible for the most comon form of dementia among old people.)Causes of this disease are not clear but genes and environmental factors seem to play a major role. (lien au dessus) It is characterized by extensive neuronal death, shrinkage of the brain and also the presence of amyloid plaques into the brain.( article principale) These plaques are concentrated with Aβ peptide which results from the anormal cleavage of APP by successive action of the β and γ secretases. The alteration in copper homostasis is directly related to the progression of Alzheimer disease. The impact of Cu(II) on the aggregation of Aβ peptide is still discussed even if Cu(II) is find in elevated concentration in these plaques. for more information you can follow the link : [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001767/ Alzheimer disease] | An Alzheimer disease is responsible for the most comon form of dementia among old people.)Causes of this disease are not clear but genes and environmental factors seem to play a major role. (lien au dessus) It is characterized by extensive neuronal death, shrinkage of the brain and also the presence of amyloid plaques into the brain.( article principale) These plaques are concentrated with Aβ peptide which results from the anormal cleavage of APP by successive action of the β and γ secretases. The alteration in copper homostasis is directly related to the progression of Alzheimer disease. The impact of Cu(II) on the aggregation of Aβ peptide is still discussed even if Cu(II) is find in elevated concentration in these plaques. for more information you can follow the link : [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001767/ Alzheimer disease] | ||
The differents domains involved into the aB dimerisation aren't yet wery well known, but it seems that E1 and E2 are playing a major role. E1 contains the copper-binding site domain and also the Growth Factor-like Domain, rather than E2 contains the Central APP domain. Those two regions are located in the extracellurlar space. <ref> PMID : 20400860 </ref> | The differents domains involved into the aB dimerisation aren't yet wery well known, but it seems that E1 and E2 are playing a major role. E1 contains the copper-binding site domain and also the Growth Factor-like Domain, rather than E2 contains the Central APP domain. Those two regions are located in the extracellurlar space. <ref> PMID : 20400860 </ref> | ||
If the CuBD (located in E1 region) does contribute to APP dimerisation without Cu ions, that mean that the Cu binding may reduce AB production, either by shifting the monomer-dimer equilibrium to favor monomer form, or by re-orienting the dimer form, which disfavour the aB production. | |||