1fsu: Difference between revisions
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4-SULFATASE (HUMAN)
OverviewOverview
BACKGROUND:. Sulfatases catalyze the hydrolysis of sulfuric acid esters, from a wide variety of substrates including glycosaminoglycans, glycolipids and steroids. There is sufficient common sequence similarity, within the class of sulfatase enzymes to indicate that they have a common, structure. Deficiencies of specific lysosomal sulfatases that are involved, in the degradation of glycosamino-glycans lead to rare inherited clinical, disorders termed mucopolysaccharidoses. In sufferers of multiple sulfatase, deficiency, all sulfatases are inactive because an essential, post-translational modification of a specific active-site cysteine residue, to oxo-alanine does not occur. Studies of this disorder have contributed, to location and characterization of the sulfatase active site. To, ... [(full description)]
About this StructureAbout this Structure
1FSU is a [Single protein] structure of sequence from [Homo sapiens] with CA and CL as [ligands]. Active as [N-acetylgalactosamine-4-sulfatase], with EC number [3.1.6.12]. Structure known Active Sites: MEB and SAL. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of a human lysosomal sulfatase., Bond CS, Clements PR, Ashby SJ, Collyer CA, Harrop SJ, Hopwood JJ, Guss JM, Structure. 1997 Feb 15;5(2):277-89. PMID:9032078
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