1far: Difference between revisions
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Revision as of 16:07, 30 October 2007
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RAF-1 CYSTEINE RICH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
OverviewOverview
The Raf-1 protein kinase is the best-characterized downstream effector of, activated Ras. Interaction with Ras leads to Raf-1 activation and results, in transduction of cell growth and differentiation signals. The details of, Raf-1 activation are unclear, but our characterization of a second, Ras-binding site in the cysteine-rich domain (CRD) and the involvement of, both Ras-binding sites in effective Raf-1-mediated transformation provides, insight into the molecular aspects and consequences of Ras-Raf, interactions. The Raf-1 CRD is a member of an emerging family of domains, many of which are found within signal transducing proteins. Several, contain binding sites for diacylglycerol (or phorbol esters) and, phosphatidylserine and are believed to play a role in membrane, translocation and ... [(full description)]
About this StructureAbout this Structure
1FAR is a [Single protein] structure of sequence from [Homo sapiens] with ZN as [ligand]. Structure known Active Sites: ZN1 and ZN2. Full crystallographic information is available from [OCA].
ReferenceReference
The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site., Mott HR, Carpenter JW, Zhong S, Ghosh S, Bell RM, Campbell SL, Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8312-7. PMID:8710867
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