1f3z: Difference between revisions
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Revision as of 16:07, 30 October 2007
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IIAGLC-ZN COMPLEX
OverviewOverview
In Escherichia coli, the glucose-specific phosphocarrier protein of the, phosphotransferase system (PTS), IIAGlc (IIIGlc in older literature), is, also the central regulatory protein of the PTS. Depending upon its state, of phosphorylation, IIAGlc binds to a number of different proteins that, display no apparent sequence homology. Previous structural studies, suggested that nonspecific hydrophobic interactions, specific salt, bridges, and an intermolecular Zn(II) binding site contribute to the wide, latitude in IIAGlc binding sites. Two new crystal forms of IIAGlc have, been solved at high resolution, and the models were compared to those, previously studied. The major intermolecular contacts in the crystals, differ in detail, but all involve the hydrophobic active site of IIAGlc, ... [(full description)]
About this StructureAbout this Structure
1F3Z is a [Single protein] structure of sequence from [Escherichia coli] with ZN as [ligand]. Active as [Protein-N(pi)-phosphohistidine--sugar phosphotransferase], with EC number [2.7.1.69]. Structure known Active Site: ZN. Full crystallographic information is available from [OCA].
ReferenceReference
Structural studies of the Escherichia coli signal transducing protein IIAGlc: implications for target recognition., Feese MD, Comolli L, Meadow ND, Roseman S, Remington SJ, Biochemistry. 1997 Dec 23;36(51):16087-96. PMID:9405042
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